The Technology
NGs are nanovesicles derived from the cell membranes of allogeneic Mesenchymal Stem Cells (MSCs).
Using the NanoGhost technology, MSCs cell membrane is isolated and downsized to nanoparticles while retaining original architecture and characteristics.
NGs can be loaded with different therapeutics, ranging from small molecule drugs, proteins and mRNA.
Mesenchymal Stem Cells w/ Natural Tropism to Cancer
Cytoplasm
Removed
Ghosts retaining source cell membranes and targeting capabilites
Payload
Introduced
Drug loaded Nano-Ghosts w/ trageting capability
Micro Scale
Nano Scale
NanoGhost Platform Characteristics
Targeted & Selective
NGs selectively target tumors (including brain tumors) and sites of inflammation while demonstrating fast clearance from normal tissues
Versatile
NGs can be loaded with various therapeutic cargos (among others small molecules, proteins, mRNA) with wide payload size range
Crosses Physiological Barriers
NGs cross the BBB and tumor barriers (such as Pancreatic Cancer)
Broad Applicability
Proof of concept demonstrated in various oncological models
Non-Immunogenic
NGs retain MSCs immune tolerability
Off the shelf
NGs are “off-the-shelf” nanoparticles manufactured using a controlled scalable process
NanoGhost Platform Versatility
Oncology
Loaded NGs
Targeting various drugs (including mRNA) to solid tumors including pancreatic and brain cancer
Immune Oncology, other
Engineered NGs
Armed NGs ectopically expressing protein of interest (such as PD-1)
Diagnostics
NGs Loaded with Diagnostic Labels
Labelled NGs for disease imaging